2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (2418):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-134324
    8-Hydroxyadenosine
    		99.86%
    8-Hydroxyadenosine is a purine nucleoside.
    8-Hydroxyadenosine
  • HY-W022290
    5-Bromocytidine
    5-Bromocytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5-Bromocytidine
  • HY-B0158S
    Cytidine-d2
    		Chemical 99.86%
    Cytidine-d2 is the deuterium labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function.
    Cytidine-d<sub>2</sub>
  • HY-W354252
    2-Amino-9-β-D-ribofuranosylpurine
    		99.71%
    (2R,3R,4S,5R)-2-(2-amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (9-pentofuranosyl-9H-purin-2-amine) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2-Amino-9-β-D-ribofuranosylpurine
  • HY-N0157A
    Orotic acid zinc
    		Chemical 99.84%
    Orotic acid (zinc), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid (zinc) is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid (zinc) can induce hepatic steatosis and hepatomegaly in rats.
    Orotic acid zinc
  • HY-154496A
    2’-Deoxy-N3-methylcytidine hydriodide
    2’-Deoxy-N3-methylcytidine hydriodide is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’-Deoxy-N3-methylcytidine hydriodide
  • HY-13637S
    Ganciclovir-d5
    		98.6%
    Ganciclovir-d5 is the deuterium labeled Ganciclovir. Ganciclovir (BW 759), a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1).
    Ganciclovir-d<sub>5</sub>
  • HY-W402064
    N-Acetyladenosine
    		99.86%
    N-Acetyladenosine is an adenosine analog and an adenosine N6-acylated derivative. N-Acetyladenosine can be produced via the heterolytic reaction between adenosine and diacetyl peroxide.
    N-Acetyladenosine
  • HY-145791
    Dideoxycytidinene
    		98.36%
    Dideoxycytidinene (2′,3′-Didehydro-2′,3′-dideoxycytidine) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    Dideoxycytidinene
  • HY-W091788
    (2S,3R,5S)-7-Deaza-2'-deoxy-7-iodoadenosine
    		99.56%
    (2S,3R,5S)-7-Deaza-2'-deoxy-7-iodoadenosine is the isomer of 7-Deaza-2'-deoxy-7-iodoadenosine (HY-W048490), and can be used as an experimental control. 7-Deaza-2'-deoxy-7-iodoadenosine is a modified oligonucleotide containing 7-Deazaadenine.
    (2S,3R,5S)-7-Deaza-2'-deoxy-7-iodoadenosine
  • HY-W011928
    3'-NH2-ddA
    3'-NH2-ddA (3'-Amino-2',3'-dideoxyadenosine) is a monomeric raw material that can be used for nucleic acid synthesis.
    3'-NH2-ddA
  • HY-W010744
    DMT-dI
    		99.40%
    DMT-dI (5'-O-DMT-dI) is a deoxyribonucleoside containing a hypoxanthine base. DMT-dI can be used to prepare convertible nucleoside derivatives to prepare modified oligonucleotides complementary to target genes for gene editing. DMT-dI can be used to study various conditions, disorders or diseases modified by adenosine.
    DMT-dI
  • HY-129972
    Ribavirin 5'-monophosphate dilithium
    Ribavirin 5'-monophosphate dilithium is an active form of ribavirin that inhibits IMP dehydrogenase, and ribavirin itself is a broad-spectrum antiviral agent.
    Ribavirin 5'-monophosphate dilithium
  • HY-78574
    N-Benzoylcytidine
    		99.50%
    N-Benzoylcytidine is a modified cytidine analogue that can be phosphorylated by uracil-cytidine kinase (UCK1 and UCK2). N-Benzoylcytidine can be used to synthesize 2-OH protective groups for solid-phase RNA synthesis, as well as synthetic oligonucleotides for UV induction and targeted gene silencing in zebrafish embryos.
    N-Benzoylcytidine
  • HY-152448
    2’-Azido-2’-deoxycytidine
    		98.78%
    2’-Azido-2’-deoxycytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 2’-Azido-2’-deoxycytidine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. 2’-Azido-2’-deoxycytidine is an azidonucleoside,and it should be phosphorylated twice to become an inhibitor of the nucleotide reductase.
    2’-Azido-2’-deoxycytidine
  • HY-W393317
    5-Methoxycarbonylmethyl-2'-O-methyluridine
    		99.80%
    5-Methoxycarbonylmethyl-2'-O-methyluridine is a thymidine analogue. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis.
    5-Methoxycarbonylmethyl-2'-O-methyluridine
  • HY-W154568
    6-Methylpurine riboside
    6-Methylpurine riboside is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    6-Methylpurine riboside
  • HY-B0116R
    Stavudine (Standard)
    Stavudine (Standard) is the analytical standard of Stavudine. This product is intended for research and analytical applications. Stavudine (d4T) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Stavudine has activity against HIV-1 and HIV-2. Stavudine also inhibits the replication of mitochondrial DNA (mtDNA). Stavudine reduces NLRP3 inflammasome activation and modulates Amyloid-β autophagy. Stavudine induces apoptosis.
    Stavudine (Standard)
  • HY-113061R
    Pseudouridine (Standard)
    Pseudouridine (Standard) is the analytical standard of Pseudouridine. This product is intended for research and analytical applications. Pseudouridine is an isomer of the nucleoside uridine, and the most abundant modified nucleoside in non-coding RNAs. Pseudouridine in rRNA and tRNA can fine-tune and stabilize the regional structure and help maintain their functions in mRNA decoding, ribosome assembly, processing and translation[4].
    Pseudouridine (Standard)
  • HY-131802
    3'-Azido-3'-deoxyadenosine
    		98.44%
    3'-Azido-3'-deoxyadenosine is a purine nucleoside analog. 3'-Azido-3'-deoxyadenosine acts as a click chemistry reagent bearing an Azide group, which undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing an Alkyne group. 3'-Azido-3'-deoxyadenosine also undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    3'-Azido-3'-deoxyadenosine